Presentation originally created for the SASA Western Cape Anaesthesiology Update 2017, and updated for Windhoek, Namibia, April 2018.  A repository for materials on the topic follows below.

Access the presentation here if it is not displated above.

Selected References:

• Bailey, D. M., C. K. Willie, R. L. Hoiland, A. R. Bain, D. B. MacLeod, M. A. Santoro, D. K. DeMasi, A. Andrijanic, T. Mijacika, O. F. Barak, Z. Dujic and P. N. Ainslie (2016). “Surviving Without Oxygen: How Low Can the Human Brain Go?” High Alt Med Biol.
• Berger, M. M. and M. P. W. Grocott (2017). “Facing acute hypoxia: from the mountains to critical care medicine.” British Journal of Anaesthesia 118(3): 283-286.
• Cannon, B. and J. Nedergaard (2004). “Brown adipose tissue: function and physiological significance.” Physiol Rev 84(1): 277-359.
• Dunn, J. O., M. G. Mythen and M. P. Grocott (2016). “Physiology of oxygen transport.” BJA Education 16(10): 341-348.
• Fenzl, A. and F. W. Kiefer (2014). “Brown adipose tissue and thermogenesis.” Horm Mol Biol Clin Investig 19(1): 25-37.
  Grocott, M., A. Richardson, H. Montgomery and M. Mythen (2007). “Caudwell Xtreme Everest: a field study of human adaptation to hypoxia.” Crit Care 11(4): 151.
• Grocott, M. P., D. S. Martin, D. Z. Levett, R. McMorrow, J. Windsor, H. E. Montgomery and G. Caudwell Xtreme Everest Research (2009). “Arterial blood gases and oxygen content in climbers on Mount Everest.” N Engl J Med 360(2): 140-149.
  Grocott, M. P., S. D. Martin, M. H. Wilson, K. Mitchell and S. Dhillon (2010). “Caudwell Xtreme Everest Expedition.” High Alt Med Biol 11(2).
• Gustafsson, I. M., A. Lodenius, J. Tunelli, J. Ullman and M. Jonsson Fagerlund (2017). “Apnoeic oxygenation in adults under general anaesthesia using Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) – a physiological study.” Br J Anaesthesia 118(4): 610-617.
• Mythen, M. “‘Everest in Utero’ – Lessons for critical care.”
• Mythen, M. “The oxygen trail: measurement.”
• Patel, A. and S. A. Nouraei (2015). “Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE): a physiological method of increasing apnoea time in patients with difficult airways.” Anaesthesia 70(3): 323-329.
• Tan, P. C. and A. T. Dennis (2016). “High-flow humidified nasal pre-oxygenation in pregnant women.“ Anaesthesia 71(7): 851-852.
• van der Lans, A. A. J. J., J. Hoeks, B. Brans, G. H. E. J. Vijgen, M. Visser, xEb, G. W. lle, M. J. Vosselman, J. Hansen, xF, J. A. rgensen, J. Wu, F. M. Mottaghy, P. Schrauwen and W. D. van Marken Lichtenbelt (2013). “Cold acclimation recruits human brown fat and increases nonshivering thermogenesis.” The Journal of Clinical Investigation 123(8): 3395-3403.
• West, J. B. (1993). “Acclimatization and tolerance to extreme altitude.” J Wilderness Med 4(1): 17-26.

Further references  can be obtained by emailing ross at wildmedix dot com